Biomedical Sciences Curriculum

BMS Students take the Core Courses (BIOM 200A and B) and Seminar in Biomedical Research (BIOM 201) in the Fall of their first year. Students select three Track Courses and two Seminar Track Courses in the Winter and Spring quarter. Students from all tracks take Biostatistics and Ethics in Research in the Spring and complete Laboratory Rotations in each quarter of the first year.

Students may take elective courses at any time, but must complete 15 units (8 for a letter grade) prior to graduation. Track Courses not required by the students own track may be taken as electives.

Core Courses

BIOM 200A/B Molecules to Organisms - Concepts and Approaches
BIOM 201 Seminar in Biomedical Research
BIOM 219 Ethics in Scientific Research
BIOM 285 Statistical Inference

Track Courses

BIOM 226 Hormone Action
BIOM 252 Genetics and Genomics
BIOM 253 Pathogens and Host Defense (Spring)
BIOM 253 Pathogens and Host Defense: Immunology (Winter)
BIOM 254 Molecular and Cell Biology
BIOM 255 / PHAR 255 Molecular Basis of Drug Action and Disease Therapy (Winter)
BIOM 255 / PHAR 255 Molecular Basis of Drug Action and Disease Therapy (Spring)
BIOM 256 / PATH 221/PHAR 222 Molecular Pathology of Cancer

Track Seminar Courses

BIOM 272 & 274 Seminars in Genetics and Molecular Cell Biology
BIOM 275 / PHAR 275 Seminars in Pharmacology
BIOM 276 Seminars in Physiology
BIOM 277 / PATH 225 Seminars in Molecular Pathology

Elective Courses

Students are required to take 15 graduate units as electives; of these at least 8 units must be taken for a letter grade (A-F). Note that the Teaching Requirement constitutes a recognized educational experience and counts as 4 units toward the S/U elective requirement. The elective courses are chosen by each student in consultation and with the approval of the Thesis advisor and, for students following a particular Track, by recommendation of that particular Track Leader.

Note that students are not required to affiliate with a Track and are free to choose the courses that best fulfill their training needs. Some appropriate elective courses that are currently offered are listed below. Elective courses in BMS are being developed continuously, driven by the scientific developments in biomedical research. Students should also survey the graduate level course listings offered at UCSD through TritonLink for options and availability provided by other graduate programs at the University. Students are encouraged to take elective courses throughout the period of their doctoral training. Students can take any course offered on the general campus or in the School of Medicine, as well as applying for UCSD Extension courses through OGS.

Fall

BGGN 231 - Current Concepts in Stem Cell Biology

This course is designed to convey the current state of the stem cell field. Through careful reading and weekly presentations, each student will learn the basic concepts of embryonic and adult stem cells, as well as recent findings in these rapidly advancing fields. This course is offered every year.
Course Instructor: David Traver and Steve Briggs

BIOM 218 - Current Topics in Anthropogeny

This course is based on participation at the public and private symposia organized by the Center for Academic Training and Research in Anthropogeny (CARTA) three times a year at UCSD and the Salk Institute. Participating graduate students will each be assigned to shadow and interact with one of the speakers and also write a summary of the speaker’s presentation. Requirements are participation in at least 2 meetings during each of 3 years. Includes post-symposia meetings amongst participating students and one or more anthropogeny faculty. For past Symposia see: http://carta.anthropogeny.org/symposia/past/list. Preference will be given to students who are signed up for the specialization track in anthropogeny. *PRE-REQUISITE: PRIOR INSTRUCTOR APPROVAL. (email Jesse Robie: progrep1carta@ucsd.edu)
Course Instructor: Pascal Gagneux
Course Information

BIOM 242 - Seminar in Genetics

The course aims to discuss in detail papers selected as topical in the current literature, as landmarks for past major discoveries or innovations, or as illustrations for particular points in the development of genetics, professional ethics and genetic methods. This seminar is required for students in the UCSD Genetics Training Program. Topics vary by quarter and the course is offered in the Fall, Winter and Spring.
Course Instructor: Bruce Hamilton
Course Information

CMM 220 - Cancer Cell Biology Journal Club

This course is a one-credit elective that critically evaluates, dissects and discusses current hot papers from the cancer biology research literature, including molecular biology, molecular genetics, biochemistry, signaling pathways, stem cells, and therapeutic approaches to treat cancer. Student presenters lead the discussion and dissection of the paper. Offered every in Fall, Winter and Spring quarters, course meets Tuesdays at noon, bring your lunch.
Course Instructor: Steven Dowdy

CMM 246 / BIOM 246 / MED 246 - Current Literature in Glycobiology

This course provides a forum for informally discussing current papers in glycobiology research. Topics include glycan chemistry, biochemistry, genetics, cell biology, and molecular biology in animals, plants, and microbes, as well as medical aspects of glycobiology. 1 credit per quarter. Course Director: Lars Bode, Co-Directors: Jeffrey D. Esko, Pascal Gagneux and Ajit Varki. Meets Fridays 12-1pm, BRF2 room 4103. First class meeting October 2, 2016. More information: http://grtc.ucsd.edu/Current_Lit.html (see Course Information link below)
Course Instructor: Pascal Gagneux, Ajit Varki and Jeff Esko
Course Information

CMM 252 - Current Literature in Stem Cell Biology, Medicine and Ethics

This course is offered every year
Course Instructor: Larry Goldstein

MED 275 - Science Meets the Medical Patient

To educate graduate and medical trainees on the pathogenic and therapeutic mechanisms of major human diseases, highlighting the state of current research, the diagnostics and therapeutics currently employed, and the unmet diagnostic and therapeutic needs.
Syllabus
Course Instructor: Judd Landsberg
Course Information

NEU 268 - Molecular and Cellular Neurobiology

This course is offered during the Fall in even years and is designed to provide knowledge of selected current topics in molecular and cellular neurobiology at the graduate level. Emphasis will be on gaining an advanced understanding of the central and peripheral nervous systems at the molecular and cellular levels. Topics to be addressed will include: Molecular genetics of the nervous system, receptor function, ion channels, axonal transport, molecular and genetic bases of disease in the nervous system, circadian rhythms, sensory and signal transduction, nerve growth factors, neuronal stem cells, and cellular and transgenic model systems for the study of molecular aspects of the nervous system. The lectures will represent the current literature and will require reading of primary papers to be assigned in advance. Students in all Graduate and Medical Programs with the appropriate background are encouraged to register. Prerequisites are upper division biochemistry or molecular biology courses, and some familiarity with neurobiology. Fall 2010 the class is offered from 2:30 to 3:50 pm on Tuesdays and Thursdays in Leichtag 3A05 on the La Jolla Campus. For questions, the instructor can be reached at the following: Dr. Pamela Mellon 534-1312 pmellon@ucsd.edu
Course Instructor: Pamela Mellon
Course Information

PHAR 201 - Bioinformatics 1 - Biological Data Representation and Analysis

ioinformatics is driven by the need to understand complex biological systems for which data are accumulating at exponential or near exponential rates. Such an understanding relies of the effective representation of these data and the ability to analyze these data. This is a broad topic and we focus on macromolecular structure data, which is suitably complex, to introduce the principles of formal data representation, reductionism, comparison, classification, visualization and biological inference. As such the course also serves as an introduction to Structural Bioinformatics. Format: 2-one hour lectures and six hours of practicum per week Time/Location: Wed. 12:30-2:00pm ; Friday 12:30-2:00pm 2109 Skaggs School of Pharmacy & Pharm Sci. 2nd Floor Conf. Room
Course Instructor: Philip E. Bourne

PHAR 233 / PATH 233, BIOM233 - Structural Biology of Drug Discovery

This class is taught fall quarter in ODD years by program faculty whose laboratories are actively involved in determining the three dimensional structure of complex biological macromolecules and studying their function, interactions, and inhibition. The course covers basic principles of protein chemistry , crystallization, cryo-electron microscopy, NMR, and modern techniques for Ab-initio-structural analysis.
Course Instructor: Maurizio Pellecchia

PHAR 294 / BIOM 294 - Pharmacology and Signal Transduction Journal Club

This elective is offered for 1 credit and will meet on Mondays from 12 – 1 PM. The course will start in mid-October and continue through Winter and Spring.
Course Instructor: Staff

SOM 204 - Glycobiology and Medicine Reading Group Workshop

The purpose of the reading group is to familiarize first year medical students with the field of glycobiology as it relates to human health and disease. Topics include research papers and review articles that focus on glycosylation and blood group antigens, xenotransplantation, selectin-mediated leukocyte adhesion, inflammation, innate immunity, human in-born errors of metabolism and mutant mice, receptors that mediate microbial adhesion and ulcer formation, and tumor cell antigens. Recent advances in these areas suggest novel therapeutic approaches for treating human disease. Students make semi-formal presentations of current papers in order to develop an appreciation of the field, critical thinking skills, and improved public speaking.
Course Instructor: Pascal Gagneux

SPPS 215 - Human Disease

This Human Disease course integrates previous training in histology and molecular biology into an understanding of human disease, the pathology, pathophysiology of common disease states and clinical correlates with medical therapeutics. Instruction is augmented with a computer-assisted image bank of diseases, an interactive case based approach and gross specimens.
Course Instructor: Lawrence Hansen
Course Information

SPPS 284 / BIOM 284 /PHAR 284 - Scientific Writing: Biomedical Research Papers

This course will examine the elements of writing scientific papers for publication. The course is intended for students, either graduate or pharmacy, who are actively involved in biomedical research but may also be of interest to postdoctoral fellows, residents and junior faculty. The goals of the course are to improve the students’ understanding of the component parts of a scientific paper and to improve the students’ skills in writing a scientific paper. The homework exercises and reading assignments will be essential for improving the students’ skills in writing. Class size is limited to 15 students.
Syllabus
Course Instructor: Ana Pajor

Winter

BENG 276 / CHEM 276 / MATH 276 / PHAR 276 - Numerical Analysis in Multi-Scale Biology

This hands-on laboratory course introduces students to numerical methods and computational tools for multi-scale biophysical modeling at the molecular, sub-cellular, whole cell, tissue and organ scales.
Course Instructor: Andrew McCulloch, J Andrew McCammon and Terry Sejnowski
Course Information

BGGN 230 / CHEM 221 - Intracellular Signaling Transduction: Molecular Mechanism, Network Function and Pharmacological Intervention

This class surveys a variety of signaling systems such as growth factors, G-protein coupled receptors, Ca regulation, as well as stress-responsive, inflammatory, immune response, and apoptotic pathways. Physiology, molecular mechanism and avenues for pharmacological intervention are emphasized. The importance of dynamic and combinatorial control in signaling is discussed, and experimental and conceptual approaches of Systems Biology are introduced.
Course Instructor: Michael David and Alexander Hoffmann

BIOM 242 - Seminar in Genetics

The course aims to discuss in detail papers selected as topical in the current literature, as landmarks for past major discoveries or innovations, or as illustrations for particular points in the development of genetics, professional ethics and genetic methods. This seminar is required for students in the UCSD Genetics Training Program. Topics vary by quarter and the course is offered in the Fall, Winter and Spring.
Course Instructor: Bruce Hamilton
Course Information

BIOM 253 - Pathogens and Host Defense: Immunology (Winter)

This course is offered as a three-unit course. It will consist of 18 sessions of 1.5 hour each spread over a 9-week period. The course will cover 9 topics relevant to understanding contemporary immunity. Sessions will be held on Tuesdays and Fridays of consecutive weeks.
Syllabus
Course Instructor: Maurizio Zanetti

BIOM 254 - Molecular and Cell Biology

The aim of the course is to provide students with an in-depth perspective on central questions in molecular cell biology with an emphasis on analytical reading of the primary literature. There will be two themes in the quarter-long course that are listed below. The course will meet twice a week (1.5 hr each) and will focus on active learning through student-led presentations of assigned papers, faculty coaching of student presenters prior to their presentations, and class discussions. Theme 1: CELL CYCLE REGULATION & CELL DIVISION and Theme 2: REGULATION OF GENE EXPRESSION
Course Instructor: Arshad Desai and Eugene Yeo

BIOM 255 / PHAR 255 - Molecular Basis of Drug Action and Disease Therapy (Winter)

This 2-quarter sequence considers the molecular basis of drug action, with a focus on classes of drugs treating the most common human diseases. The goal of the course is to understand the basis for these diseases, the mechanism by which currently available drug therapies work and how potential new drug targets can be discovered and translated into clinically viable therapeutic interventions. BIOM 255A is not a required prerequisite for 255B although the A/B sequence is strongly recommended, and both are required for students supported by the training grant in Pharmacological Sciences. Note that some topics may not always be given in the quarter listed. BIOM 255A – Topics include: quantitative aspects of ligand-receptor interactions and the fate of drugs in the body (drug transporters and drug metabolism); pharmacology of the autonomic nervous system; actions of histamine, circulating peptides, and prostaglandins; treatment of asthma; mechanisms and therapeutics of hypertension, heart failure, clotting disorders and hypercholesterolemia; diabetes and obesity, and cancer therapeutics.
Syllabus
Course Instructor: Paul Insel and Volker Vallon
Course Information

BIOM 256 / PATH 221/PHAR 222 - Molecular Pathology of Cancer

This class is taught by program faculty from UCSD and the Burnham Institute whose laboratories are actively engaged in cancer research. It covers a wide range of cancer-related topics at the molecular level and provides a solid basis of knowledge for students interested in the cancer problem.
Syllabus
Course Instructor: Mark Kamps
Course Information

BIOM 267 / PHAR 210/SPPS 273/MGT 217 - Drug Discovery, Development and Commercialization

This course is designed to increase knowledge of the drug discovery, development, regulatory and commercialization process. Students will have an increased understanding of how an investigational agent eventually becomes an approved drug for patient use. Lectures and a student group project will be conducted for this elective. Information meeting for students: Dec. 5th; 12-12:50 pm; PSB1120
Syllabus
Course Instructor: Joseph D. Ma and Williams Ettouati
Course Information

BIOM 275 / PHAR 275 - Seminars in Pharmacology

This seminar course will provide students with current perspectives on metabolism and its role in tissue physiology and human disease, with a focus on use of cutting-edge metabolomics approaches to understand metabolic activity. Topics to include transcriptional regulation of metabolism, chemical strategies for elucidating enzyme function, metabolic biosensors, clinical metabolomics, as well as the role of metabolic dysregulation in diabetes, heart disease and cancer.
Syllabus
Course Instructor: Mohit Jain
Course Information

BIOM 277 / PATH 225 - Seminars in Molecular Pathology

Seminars in Molecular Pathology is a weekly luncheon series (lunch provided) where Molecular Pathology Graduate Program faculty present 30-45 minute overviews of their research to first year students. Discussion follows each presentation. The Winter Quarter research lecture schedule is listed below.
Syllabus
Course Instructor: Richard Klemke

CMM 220 - Cancer Cell Biology Journal Club

This course is a one-credit elective that critically evaluates, dissects and discusses current hot papers from the cancer biology research literature, including molecular biology, molecular genetics, biochemistry, signaling pathways, stem cells, and therapeutic approaches to treat cancer. Student presenters lead the discussion and dissection of the paper. Offered every in Fall, Winter and Spring quarters, course meets Tuesdays at noon, bring your lunch.
Course Instructor: Steven Dowdy

CMM 246 / BIOM 246 / MED 246 - Current Literature in Glycobiology

This course provides a forum for informally discussing current papers in glycobiology research. Topics include glycan chemistry, biochemistry, genetics, cell biology, and molecular biology in animals, plants, and microbes, as well as medical aspects of glycobiology. 1 credit per quarter. Course Director: Lars Bode, Co-Directors: Jeffrey D. Esko, Pascal Gagneux and Ajit Varki. Meets Fridays 12-1pm, BRF2 room 4103. First class meeting October 2, 2016. More information: http://grtc.ucsd.edu/Current_Lit.html (see Course Information link below)
Course Instructor: Pascal Gagneux, Ajit Varki and Jeff Esko
Course Information

CMM 250 - Core Course in Stem Cell Biology, Medicine and Ethics

Course Instructor: Goldstein, Mercola, Belmonte, Ding, Devereaux (ethics)
Course Information

CMM 262 / BIOM 262/ BGGN 237 - Quantitative Methods in Genetics

Quantitative Methods in Genetics and Genomics is designed to teach experimental and analytical approaches in modern genetics and genomics, from experimental design through data analysis in each of several topic areas. The course will use a combination of lectures, demonstrations with a heavy emphasis on hands-on data analysis. Students will need access to a laptop. We will cover an introduction to python, R and unix and statistics. Students will use programming languages and web-based portals to analyze high-throughput sequencing datasets to analyze somatic and germline variants, cloud-based analysis for high-throughput datasets, GWAS and machine learning as applied to genetics. In past years, typical subjects will include saturation and coverage in genetic screens, hypothesis-driven gene expression assays (Northern blots, quantitative PCR, luciferase reporters, etc.), genome-wide expression assays (microarrays, sequence tag methods), genetic linkage in experimental crosses, linkage in human pedigrees, genome-wide association studies, and other approaches relevant to modern genetics and genomics research. This course is intended for advanced predoctoral students (G2 and later) in Biological and Health Sciences departments and is a requirement for students in the UCSD Genetics Training Program. 4 units.
Course Instructor: Gene Yeo
Course Information

MED 238 / BENG 238 - Molecular Biology of the Cardiovascular System

This course is a broad survey of the molecular biology of the cardiovascular system, covering the development of the heart, cardiac conduction system, and vasculature and the relevance of this to understanding and treating cardiovascular disease. Practical principles underlying utilization of the mouse as a model to study cardiovascular disease are introduced, and several mouse models of cardiomyopathy and cardiac hypertrophy are discussed. Current understanding of processes underlying atherosclerotic disease is introduced, including the role of fluid shear stress in vascular remodeling.
Course Instructor: Ju Chen and Sylvia Evans
Course Information

MED 263 - Bioinformatics Applications to Human Disease

This elective is offered as a 3 unit course in the Winter quarter with lectures on Tuesday afternoons (16:00-17:30) and computer practicals on Thursday afternoons (16:00-17:30). This course will cover the latest advances in bioinformatics and provide students with the practical skills to implement what they have learned. Specifically, students will learn how to apply bioinformatic analyses related to pathogen evolution, sequence data, microarray gene expression data, genomics and proteomics to the study of human diseases.
Course Instructor: Christopher Woelk and Sergei Kosakovsky Pond
Course Information

MED 296 / PATH 296 - Med-into-Grad

The program’s strategy is to place graduate students within one of eleven medical groups that conduct the ongoing diagnosis and treatment of various types of human disease related to the graduate students area of thesis research. These medical groups reside within the Departments of Medicine, Neurosciences, and Pediatrics. Please contact Mark Kamps (mkamps@ucsd.edu) regarding course enrollment.
Course Instructor: Mark Kamps
Course Information

PATH 220 - Mechanisms of Neurologic Disease

The course covers the molecular basis and structural basis of neurodegenerative disease. Emphasis is placed on the underlying mechanisms and propagation of neural degeneration as well as potential avenues for molecular intervention. This course is offered winter quarter in EVEN years except: NOT OFFERED WINTER 2014
Course Instructor: Nigel Calcutt

PHAR 231 / BIOM 231 - Contemporary Topics in The Pharmacological Sciences - Flourescence Spectroscopy and Microscopy Techniques

The course will be offered for 1 credit and will take place during any week of winter quarter, depending on the instructor’s schedule. The course is offered only in even years
Course Instructor: Palmer Taylor and Roger Tsien

PHAR 235 / BIOM235/ SPPS 218 and 219 - Pharmacogenomics

This course is part of the Contemporary Pharmacology (SPPS 218) course and meets one of the elective course requirements for trainees on the Pharmacological Sciences Grant (see attached curriculum). The course is now two credits with an increased time commitment. All of the presentations will be done by faculty, and also includes invited local and international experts. As with any contemporary and growing subject area, much of the material is not well honed and in text books. The lecturers will provide reference and background materials, most of which will be distributed electronically.
Syllabus
Course Instructor: Joe Ma

PHAR 240 / SOM 240 / SPPS 260 - Pharmacologic Analysis of Physiologic Systems: Introduction to Invasive Clinical Technique

The elective, SOM/PHARM 240, will be offered for 2 credits and will occur in the Winter quarter, on selected Tuesday afternoons (1 - 4 PM). This elective offers lectures, hands-on training, and analysis in autonomic, cardiovascular, and pulmonary physiology and pharmacology; some students find the course a very useful adjunct to the Winter quarter courses, and a good way to observe, to review and to cement in place the principles being studied in OP and POP.
Syllabus
Course Instructor: Tony Yaksh and Francisco Villarreal
Course Information

PHAR 294 / BIOM 294 - Pharmacology and Signal Transduction Journal Club

This elective is offered for 1 credit and will meet on Mondays from 12 – 1 PM. The course will start in mid-October and continue through Winter and Spring.
Course Instructor: Staff

SPPS 240 - Histology

This course presents the microscopic anatomy which comprises the structural basis of normal physiology. Such knowledge is essential for understanding disease mechanisms in terms of altered structure and function of the human body. Students are expected to identify the specialized cells, tissue and organs, and understand the structural basis of their function. Emphasis is placed on microscopic study conducted in small groups in laboratories under close supervision by the faculty and supplemented with MedPics, a computer-assisted image bank. Discussions will include drug mechanisms and some review of anatomy and physiology.
Course Instructor: Nigel Calcutt
Course Information

SPPS 273 / PHAR210/ BIOM 267/ MGT 217 - Drug Discovery, Development & Commercialization

Course Instructor: Joseph Ma & Williams Ettouati

SPPS 298/276 - Frontiers in Therapeutic and Diagnostic Delivery

Seminar series that will discuss latest, cutting edge research done on new novel drug, protein and diagnostic delivery systems. Students are expected to attend eight out of 10 lectures. Once the quarter is over students will select the one lecture which piqued their interest the most and will write a page describing its research and its potential impact on Biomedical sciences. To enroll please contact Shelly Fromholtz, Sfromholtz@ucsd.edu.
Course Instructor: Adah Almutairi

Spring

BGGN 226 - Graduate Animal Virology

This course consists of a review of fundamental concepts together with an in-depth analysis of the structure, replication strategies, subversion of the host cell, and in vivo pathogenesis of selected animal viruses. The format of this section includes lectures and detailed discussion of selected papers in the current literature. The course is given every year in the Spring quarter and meets once a week for 3 hours.
Course Instructor: Deborah Spector and Faculty from the Division of Biological Sciences, School of Medicine, Salk Institute, and La Jolla Institute of Allergy and Immunology

BIOM 226 - Hormone Action

This graduate course covers recent advances in research into hormone action, molecular and cellular endocrinology, sexual differentiation and development, growth and metabolism, and endocrinological aspects of various diseases. The course is for graduate students who have an interest in learning about endocrinology and neuroendocrinology at the molecular and physiological levels in both humans and animal models. This course is offered in the Spring.
Course Instructor: Alexander (Sasha) Kauffman

BIOM 234 / PHAR 234 - Careers in Biomedical Sciences

The course will meet for 2 hrs a day, Monday - Friday, from 3:00-5:00 p.m., during one week in May. The course is open to all students, however if enrollment needs to be limited, preference will be given to those who have not taken the course previously and to those beyond their first year. Please contact Pat Luetmer, X24107, pharmeducation@ucsd.edu, for questions.
Course Instructor: Joan Heller Brown

BIOM 242 - Seminar in Genetics

The course aims to discuss in detail papers selected as topical in the current literature, as landmarks for past major discoveries or innovations, or as illustrations for particular points in the development of genetics, professional ethics and genetic methods. This seminar is required for students in the UCSD Genetics Training Program. Topics vary by quarter and the course is offered in the Fall, Winter and Spring.
Course Instructor: Bruce Hamilton
Course Information

BIOM 252 - Genetics and Genomics

This course will focus on genes, genetic pathways and current technology that define the underpinnings of human disease. Topics will rotate. The format of this 3 unit course will be 9 (nine) 2-day block topics per week consisting of didactic lectures by faculty (Day 1) and student presentation of assigned papers (Day 2).
Syllabus
Course Instructor: Frank Furnari and Radha Ayysgari

BIOM 253 - Pathogens and Host Defense (Spring)

Topics to be covered include molecular and cellular mechanisms of viral, bacterial, and protozoan pathogenesis. Immune defenses of the host will also be addressed. Weekly meetings will consist of faculty overview of principles and student led discussion of key papers.
Course Instructor: Victor Nizet
Course Information

BIOM 255 / PHAR 255 - Molecular Basis of Drug Action and Disease Therapy (Spring)

This 2-quarter sequence considers the molecular basis of drug action, with a focus on classes of drugs treating the most common human diseases. The goal of the course is to understand the basis for these diseases, the mechanism by which currently available drug therapies work and how potential new drug targets can be discovered and translated into clinically viable therapeutic interventions. BIOM 255A is not a required prerequisite for 255B although the A/B sequence is strongly recommended, and both are required for students supported by the training grant in Pharmacological Sciences. Note that some topics may not always be given in the quarter listed. BIOM 255B – Topics include: pharmacology of the central nervous system, treatment of pain, headache and seizure disorders; drugs to promote sleep and to treat psychiatric disorders (antidepressants and antipsychotics); local and general anesthetics; ethanol; drugs of abuse.
Course Instructor: Joan Heller Brown and Bill Joiner
Course Information

BIOM 272 & 274 - Seminars in Genetics and Molecular Cell Biology

This course will provide perspective on selected seminars representing diverse areas of modern biomedical sciences. Each year's topics vary but are usually variations of molecular cell biology, genetics/genomics, stem cell biology, immunology/virology, and neurobiology. The course consists of one selected seminar on campus and one class meeting (Friday 11:00-1:00 pm, CMME 2047) per week. The Friday meetings will combine a student-led discussion of the previous week's seminar (post-session) with an introduction to the upcoming seminar by a guest lecturer (pre-session). The guest lecturer (a senior student, postdoctoral fellow or faculty member from the local research community who works on a related research topic) will introduce the upcoming seminar following a format designed to encourage student participation. For previous class information, please go to: http://zheng.ucsd.edu/index.php?menu=courses
Course Instructor: Karen Oegema and Binhai Zheng
Course Information

BIOM 276 - Seminars in Physiology

This course will introduce students to current research questions and methods in different physiological specialties and it is designed for graduate students of all levels. We meet with a journal club at noon on Tuesdays for a student-led discussion of articles providing background for a Physiology seminar on Wednesday 3-4PM. We focus primarily on cardiorespiratory physiology to introduce students to the latest questions and techniques used in systemic physiology research. Students will also be registered for the Experimental Biology conference in San Diego April 2-6, 2016, which hosts symposia and posters for the American Societies of Physiology, Pharmacology & Experimental Therapeutics, Biochemistry & Molecular Biology, and Investigative Pathology.
Course Instructor: Frank Powell

CHEM 264 / BIMM 164 / BGGN 264 - Structural Biology of Viruses

This course provides a broad introduction to the structural biology of viral pathogens. Viruses (‘infection machines’) are of course the subject of intense interest in large part owing to their direct impact on human health, the food supply, and environment, but also because they provide an outstanding means to explore and understand fundamental biological processes. The composition and basic structures of viruses will be discussed, including those that are simple and either spherically or helically symmetric, to those that are complex or pleomorphic. Overviews of the primary methods by which structural information on viruses is derived will be given. These include: X-ray crystallography, solution X-ray scattering, X-ray fiber diffraction, NMR spectroscopy, transmission electron cryo-microscopy, single particle and three-dimensional image reconstruction, and electron cryo-tomography. Virus structure lies at the heart of understanding the mechanisms by which these nano-machines infect cells. Indeed, virus strcture has evolved to facilitate all stages of the viral life cycle from recognition and binding to host cell receptors, uptake, genome release, replication, assembly, budding/lysis/release, transmission from host to host, and host defense mechanisms (e.g. immune recognition).
Course Instructor: T. S. Baker

CMM 220 - Cancer Cell Biology Journal Club

This course is a one-credit elective that critically evaluates, dissects and discusses current hot papers from the cancer biology research literature, including molecular biology, molecular genetics, biochemistry, signaling pathways, stem cells, and therapeutic approaches to treat cancer. Student presenters lead the discussion and dissection of the paper. Offered every in Fall, Winter and Spring quarters, course meets Tuesdays at noon, bring your lunch.
Course Instructor: Steven Dowdy

CMM 225 / MED 225 / BIOM 222 / CHEM 237/ BGGN 236 - Essentials of Glycobiology

The primary aim of this course is to provide an easy-to-understand, succinct, and current overview of the fundamental facts, concepts, and methods in glycobiology. The course is supported by the textbook, Essentials of Glycobiology, co-authored and edited by the lecturers. The book provides background material for discussion. Grading will be based on regular attendance and active participation in class discussion. Credit: 4 units. Letter grade and S/U grading options available. The course is offered in even years in the Spring and will be offered in Spring 2012
Course Instructor: Ajit Varki, Jeff Esko and other Faculty

CMM 246 / BIOM 246 / MED 246 - Current Literature in Glycobiology

This course provides a forum for informally discussing current papers in glycobiology research. Topics include glycan chemistry, biochemistry, genetics, cell biology, and molecular biology in animals, plants, and microbes, as well as medical aspects of glycobiology. 1 credit per quarter. Course Director: Lars Bode, Co-Directors: Jeffrey D. Esko, Pascal Gagneux and Ajit Varki. Meets Fridays 12-1pm, BRF2 room 4103. First class meeting October 2, 2016. More information: http://grtc.ucsd.edu/Current_Lit.html (see Course Information link below)
Course Instructor: Pascal Gagneux, Ajit Varki and Jeff Esko
Course Information

CMM 264 / SPPS 268 - Proteomics for Biologists

The goal of the course will be to introduce the basics of mass spectrometry and proteomic applications for biomedical research. Students will gain knowledge of concepts in proteomics and understanding of applications to biological questions. The course will consist of one 2-hr class per week. Each class will consist of a one hour lecture by a faculty expert, with the second hour composed of student presentations of journal articles and tours of mass spectrometry laboratories.
Course Instructor: Vivian Hook and Huilin Zhou

MED 224 / BIOM 264 - Molecular and Cellular Basis of Disease

This course is a seminar type lecture series by different experts on the molecular and cellular basis of different diseases and their therapies. There will be a one hour lecture followed by up to an hour of discussion. There will be no final exam but students will be expected to submit a paper on any one topic discussed.
Course Instructor: Nazneed Dewji

MED 252 / BIOM 250 - Molecular and Modern Methodologies in Physiological Sciences

The purpose of this course is to familiarize students with modern molecular and cellular approaches and methodologies for the study of physiological and pathophysiological processes. An integral part of each lecture will be a review of the background physiology of the system under study and how the specific methods presented are utilized to address the scientific questions posed. The intent of the course is to demonstrate to students how to approach a physiologically relevant question with state-of-the-art molecular and cellular techniques. This course is offered in the even years.
Course Instructor: Mike Hogan

MED 271 - Gene Therapy and Molecular Medicine

You will be expected to attend at least 8 of the 10 lectures to receive a passing grade in this class. Also, if you are taking MED271 for a letter grade and would like to receive an A, you will need to identify, read, and critically review an original research paper related to one of the lectures (see next page). Finally, as a seminar participant we encourage you to play an active role in your education. In other words, feel free to ask questions during the lectures if speakers are unclear, you require more background information, or you are curious about issues related to the lecture. You should also feel free to contact lecturers outside of class to further supplement your educational experience.
Course Instructor: Eyal Raz & Anthony Horner
Course Information

NEU 266 / BGGN 268 - Developmental of Neutral Circuits

This course is offered in even years.
Course Instructor: Yishi Jin/Yimin Zou/Nick Spitzer

NEU 277 - Neuropsychophamacology

Neuropsychopharmacology begins by introducing some basic principles and methods of importance in pharmacological studies relevant to psychoactive drugs. The remainder of the course reviews the current status of research on major categories of drugs of abuse and both preclinical and clinical aspects of psychotherapeutic drugs.
Course Instructor: Ron Kuczenski/Mark Geyer

PATH 223 / BIOM 227 - Mouse Models for Human Disease

2-credit course. In vivo studies are becoming increasingly important in the post-genomic era for validating and extending cellular and molecular approaches into complex physiology. This course provides an overview of the use of mouse models in biomedical research. It is intended to complement PATH 234/MED234/BIOM238/BGGN234 by providing general discussions of mouse models of disease that are coordinated with the subsequent laboratory sessions. Initial sessions will discuss general mouse biology, genetics, and technologies for generating mutant mice. This will be followed by several sessions on mouse models in specific areas of human disease research, with a focus on model selection, methodological approaches, and data interpretation. Student participation will include opportunities for discussion as well as 10-15 minutes student presentations of original research papers employing murine models. Attendance required. Grading: S/U
Syllabus
Course Instructor: Peter Ernst

PATH 234 / MED234, BGGN234, BIOM238 - Practical Histopathology of Mouse Models of Human Disease

Course Instructor: Nissi Varki

PHAR 228 / PATH 228, BIOM 228 - Modern Drug Discovery Technologies

The course covers the basic principles of a wide range of drug discovery approaches and provides the students with real examples recently published from Sanford-Burnham Institute for Medical Research’s faculty. This class is taught by program faculty, whose laboratories are actively involved in discovering and developing small organic molecules against therapeutically relevant targets and held at the Sanford-Burnham Institute. This course is offered spring quarter in EVEN years.
Course Instructor: Guy Salvesen
Course Information

PHAR 294 / BIOM 294 - Pharmacology and Signal Transduction Journal Club

This elective is offered for 1 credit and will meet on Mondays from 12 – 1 PM. The course will start in mid-October and continue through Winter and Spring.
Course Instructor: Staff

SPPS 298/276 - Frontiers in Therapeutic and Diagnostic Delivery

Seminar series that will discuss latest, cutting edge research done on new novel drug, protein and diagnostic delivery systems. Students are expected to attend eight out of 10 lectures. Once the quarter is over students will select the one lecture which piqued their interest the most and will write a page describing its research and its potential impact on Biomedical sciences. To enroll please contact Shelly Fromholtz, Sfromholtz@ucsd.edu.
Course Instructor: Adah Almutairi