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Our laboratory is investigating the contribution of molecular genetics and xenobiotic receptor control on the regulation of human UDP-glucuronosyltransferase (UGT) and cytochrome P450 (CYP) genes. The regulation of these genes dictates the fate through metabolism of most therapeutic drugs and many environmentally generated toxicants. To understand how these genes and their gene products function in vivo, transgenic and knockout technologies are being developed that allow for pharmacokinetic, regulatory and functional studies to be conducted in humanized animal models.

Track(s):
Molecular Pharmacology