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Our laboratory is interested in the structure and function of receptors, enzymes and adhesion molecules involved in neurotransmission. We have been studying functional coupling of receptors to cellular responses, specificity of ligand recognition by nicotinic acetylcholine receptors and acetylcholinesterase, and the structures of cholinesterases, neuroligins and nicotinic receptors. With Barry Sharpless’ group at The Scripps Research Institute (TSRI), we have been employed these molecules as templates for “freeze-frame, click chemistry” synthesis of selective agonists and antagonists. Another area of investigation involves the regulation of expression of the genes encoding these proteins during differentiation and synaptogenesis in neurons, skeletal muscle and hematopoietic cells.

Track(s):
Molecular Pharmacology
Molecular Pathology

BMS Focus Areas:
Bioinformatics