Research Interests:
The role of growth/differentiation factors in mammalian reproductive system, specifically their control of ovarian follicle development. Particular interest focused on the role of TGF-b superfamily members, such as activins, BMPs, and GDFs in granulosa cell cytodifferentiation and proliferation as well as specific ovarian disorders including polycystic ovary syndrome and ovarian cancer. Molecular, cellular and biochemical approaches are utilized.
Track(s):
MCB
BMS Focus Areas:
Developmental Biology
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Hashimoto, O., Moore, R.K., Shimasaki, S. (2005) Post-translational processing of mouse and human BMP-15: potential implication in the determination of ovulation quota. Proc. Natl. Acad. Sci. U.S.A.102:5426-5431.
Yoshino, O., McMahon, HE., Sharma, S., Shimasaki, S. (2006) A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouse. Proc. Natl. Acad. Sci. U.S.A. 103:10678-10683.
Lerch, T.F., Shimasaki, S., Woodruff, T.K., Jardetzky, T.S. (2007) Structural and biophysical coupling of heparin and activin binding to follistatin isoform functions. J. Biol. Chem. 282:15930-15939, 2007.
Sugiura, K., Su, Y.Q., Diaz, F.J., Pangas, S.A., Sharma, S., Wigglesworth, K., O'brien, M.J., Matzuk, M.M., Shimasaki, S., Eppig, J.J. (2007) Oocyte-derived BMP15 and FGFs cooperate to promote glycolysis in cumulus cells. Development 134:2593-603.
McMahon, HE., Hashimoto, O., Mellon, PL., Shimasaki, S. (2008) Oocyte-specific over-expression of mouse BMP-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice. Endocrinology 149:2807-2815.
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