Research Interests:
Dr. Ren's laboratory is interested in understanding how the complex gene regulatory networks in mammalian cells control cellular proliferation and differentiation. The research is divided into two general areas: 1) the development of genomics and bioinformatics tools that allow genome wide identification of regulatory targets for transcription factors; and, 2) the application of these tools to study of transcription factors that play critical roles in tumorigenesis. Projects include: 1, molecular characterization of c-myc transformation of Burkitt's lymphoma; 2, molecular characterization genetic programs in acute myeloid leukemia (AML); 3, development of human and mice promoter microarrrays to map transcription factor targets; 4. studies of gene regulatory networks controlling human cell cycle. Approaches involve DNA microarrays, genome expression analysis, mammalian cell culture, mice models, and molecular biology techniques.
Track(s):
Genetics
Molecular Pharmacology
BMS Focus Areas:
Bioinformatics
Cancer Biology
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