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We are interested in the molecular mechanics of cell division. Our work is currently focused in two areas: centrosome duplication and maturation, and the assembly and constriction of the contractile ring during cytokinesis. Defects in both processes are postulated to contribute to tumorigenesis. To study these processes, we are using the early embryo of the soil nematode nematode Caenorhabditis elegans as a metazoan model system. In C. elegans, efficient turnover-independent depletion of maternally loaded proteins following RNA-mediated interference (RNAi) makes it feasible to analyze the first mitotic division of embryos depleted of any targeted gene product. Our approaches include RNAi-based functional genomics, single-cell high-resolution microscopy assays and biochemical characterization of native protein complexes.

Track(s):
MCB
Molecular Pathology