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My laboratory is investigating the mechanisms by which extracellular stimuli regulate the expression of mammalian genes and modulate the proliferation, differentiation and survival of different cell types. We focus on both transcriptional and post-transcriptional (control of mRNA turnover) control mechanisms. However, we are mostly interested in the role of protein kinases and other signaling molecules (TRAF and RAS proteins, for example) in these regulatory processes. Much of the current research deals with the response of mammalian cells to pro-inflammatory stimuli, different forms of radiation and oxidative stress. We are particularly interested in the signaling mechanisms used by tumor necrosis factor (TNF), interleukin 1 (IL-1) and other molecules which activate members of the TNF and IL-1 receptor families. Another area of major interest are the mechanisms that link inflammation and cancer. The lab is using a variety of approaches spanning the entire spectrum from protein purification to the generation and analysis of mutant mouse strains.

Track(s):
Molecular Pharmacology


BMS Focus Areas:
Cancer Biology