Research Interests:
The research in my laboratory is directed at understanding the relationship between growth and development of the human endocrine pancreas, with the ultimate goal of developing a cell transplantation therapy for diabetes. We have created immortalized human pancreatic endocrine cell lines that can be induced to differentiate into functional beta cells exhibiting glucose-responsive insulin secretion in vitro and in vivo. Currently, we are studying the cell lines at a basic and applied level so that it will be possible to move into large animal models as soon as possible.
Track(s):
Genetics
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Wang S, Beattie G, Hayek A, and Levine F. Development of a pseudotyped retroviral vector expressing dominant oncogenes from a lacO-modified inducible LTR promoter. Gene 182:145-150, 1996.
Wang S, Beattie GM, Mally MI, Cirrulli V, Itkin-Ansari P, Lopez AD, Hayek A and Levine F. Isolation and characterization of a cell line from the epithelial cells of the human fetal pancreas. Cell Transplantation 6:59-67, 1997.
Wang S, Beattie GM, Mally MI, Lopez AD, Hayek A, Levine F. Analysis of a human feta pancreatic islet cell line. Transplantation Proceedings 29:2219, 1997.
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