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My lab uses genetics, molecular biology and cell biology to understand development and disease in the mammalian nervous system. We are particularly interested in the integration of signal transduction pathways required for differentiation in Purkinje neurons of the cerebellum, and especially the integration of pathways through the orphan nuclear receptor transcription factor RORa, which is mutated in staggerer mutant mice. We are also interested in genetic architecture of susceptibility to neurodegeneration in mechanisms related to human disease, including protein aggregation disorders and modifier genes that influence the penetrance of genetic disease pathways. Using mouse as one experimental system has led us to examine pre-mRNA processing and mRNA nuclear export pathway as important modifiers of retrovirus-induced mutations that have neurological phenotypes.

Focus Areas: Neurobiology, Developmental Biology

Track(s):
Genetics
MCB

BMS Focus Areas:
Neurobiology
Developmental Biology