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Dr. Glass' laboratory investigates the mechanisms by which sequence-specific transcription factors regulate the development and function of macrophages. A major focus is on members of the nuclear receptor, NF-kB, AP-1 and Ets families of transcription factors. Studies over the past few years have led to the identification of a large number of coactivator and corepressor complexes that interact with these factors in a ligand or signal-dependent manner and mediate their transcriptional effects. Current efforts are to determine the biochemical and biological roles of these transcription factors and their associated co-regulators in controlling macrophage differentiation and function. A combination of biochemical, cellular and in vivo model systems are used, incorporating macrophage-specific knockouts, microarray technologies and bioinformatics approaches, to unravel the contributions of specific factors to the development of specialized macrophage functions and the pathogenesis of atherosclerosis and inflammatory diseases.

Primary Track: Molecular Cell Biology
Secondary Track: Microbiology/Immunology

Track(s):
MCB
Microbiology/Immunology

BMS Focus Areas:
Endocrinology