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Mechanisms of pre-messenger RNA processing, regulation of alternative splicing, and the organization of the splicing apparatus in mammalian cells. A variety of approaches are taken to identify splicing factors and their regulators and to elucidate their functions in constitutive and regulated splicing. In particular, we have been focusing on signaling pathways in pre-mRNA splicing to understand how RNA splicing is coordinately regulated in and/or responsible for specific events associated with development, differentiation, and diseases. We have developed a novel genomic technology to conduct large-scale analysis of regulated splicing in development and disease. More recently, we have extended the technology to genome-wide promoter profiling and analysis of protein-DNA and DNA-DNA interactions on tiling arrays. We are using these tools to address how transcription is initiated and the process is coupled with downstream events in gene expression.

Track(s):
MCB
Molecular Pathology

BMS Focus Areas:
Cancer Biology