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The main interests of our cell biology lab are focused on the interplay between cell signaling and protein trafficking. Recently we have discovered a number of new molecules involved in G-protein mediated signaling pathways, including GAIP, RGS-PX1, GIPC and calnuc. These new proteins serve to modulate G protein signaling and to link G protein signaling to growth factor receptor trafficking. To define the molecular mechanisms involved we are using a combination of molecular (yeast two hybrid, phage display), proteomics (mass spec), biochemical (cell fractionation, in vitro assays), bioinformatics, and morphologic (immunofluorescence, immunoelectron microscopy, confocal and deconvolution microscopy) approaches to study a variety of mammalian systems including cells in culture, mouse mutants and mammalian tissues.

Track(s):
MCB
Molecular Pharmacology