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Our laboratory has identified a superfamily of proteins encoding receptors for steroids, retinoids (vitamin A), and thyroid hormones. Analyses of these receptors show they are hormone dependent transcription factors and provide a molecular link between transcriptional regulation and organ physiology. Our isolation of co-factors for these receptors has helped to establish a biochemical basis for hormone signalling. Technology for these studies includes X-ray crystallography, gene knockouts, chromatin modification and transfection. Recently, we have identified two new mammalian hormones controlling adipogenesis and fat metabolism, and are currently characterizing their roles in physiology and human disease. By metabolic engineering of muscle, we have created a fatigue resistant "Marathon" mouse that runs twice the distance of normal littermates.

Track(s):
MCB
Molecular Pharmacology

BMS Focus Areas:
Bioinformatics
Endocrinology