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The focus of our lab is to define genetic pathways underlying heart development and to apply that understanding to both congenital and adult heart disease. A basic understanding of heart development is key toward understanding congenital heart disease. Building a functioning heart requires the specification and interaction of a number of cell lineages of distinct function. Our lab is trying to understand the stepwise process by which mesodermal precursors become committed to cardiac progenitors, and then specified to become distinct cardiac lineages. We are also studying several stem cell populations which give rise to distinct cardiovascular lineages. Our lab utilizes mouse as a model system.

Track(s):
Molecular Pharmacology


BMS Focus Areas:
Stem Cells