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Development of novel cancer drugs and drug delivery systems and investigation of the molecular mechanisms of resistance to antineoplastic agents. The efficacy, pharmacokinetics and toxicology of new cancer drugs are studied in preclinical models and clinical trials. Mechanisms of resistance are studied in cell lines and tumor models using molecular, genetic, biochemical and cellular pharmacologic techniques. Particular attention is focused on transporters by which drugs enter and exit from tumor cells, and the repair systems that cells utilize to recover from drug-induced injury.

Track(s):
Molecular Pharmacology


BMS Focus Areas:
Cancer Biology