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Activation of cell death pathways is a common occurrence in cardiovascular disease and contributes to the development of heart failure. We are interested in understanding the molecular pathways that regulate the life and death of cardiac myocytes. Using genetic and molecular biology approaches, we are elucidating the role that the Bcl-2 proteins play in regulating cell death in myocardial cells. The Bcl-2 family members are pro- and anti-apoptotic proteins that regulate the mitochondrial pathway of apoptosis in cells, including those of the myocardium.

In addition, anthracyclines are among the most effective chemotherapeutic agents, but they are problematic because they are associated with cardiotoxicity. Cardiac stem cells provide a mechanism for minor repair and ongoing cell turnover in the heart. Our data suggest that anthracyclines impair stem cell function, resulting in a heart that is more susceptible to stress. We are currently investigating exactly how anthracylines interfere with stem cell function.

Track(s):
Molecular Pharmacology
MCB