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My laboratory is interested in the signaling networks that control immune responses. Over the past few years many important signaling proteins have been identified, but understanding how they control immune responses requires us to look at how they function together. To investigate the functions and regulation of signaling networks we have developed a mechanistic Systems Biology approach that combines biochemical, cell biological, genome-wide measurements and computational modeling work. This allows us to focus on the signaling systems’ emergent properties, such as dynamic control, signaling crosstalk, and memory that play important roles in determining the specificity and effectiveness of immune responses. We study tissue cells, macrophages, dendritic cells, B-cell and T-cells, as well as their interaction with each other. NFκB and interferon signaling systems are the primary focus.

Track(s):
Microbiology/Immunology