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My laboratory is working towards a better understanding of how blood cells first arise in the embryo from hematopoietic stem cells. We are leveraging the many advantages that the zebrafish system offers to study the ontogeny of hematopoiesis and immunity. These include the easy visualization of blood cells in the translucent embryo and the ability to dissect genetically the pathways important for blood cell specification, maintenance and function. We have recently initiated studies on the immune defenses of zebrafish, both in the embryo and in the adult. We are examining the components of the immune response, with the goals of identifying the effectors of innate immunity, developing models of bacterial infection, and determining when and where antigen presentation occurs to prime the adaptive immune response. Our ultimate goal is to observe and dissect the immune response in real time in living animals through the use of multiparameter fluorescent imaging and genetics.

Track(s):
Genetics
Microbiology/Immunology