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Research in my laboratory is divided in two groups: 1) Mitochondrial Mechanisms of Disease and Development, and 2) Evolutionary Systems Biology and Marine Metagenomics. Areas of active research in our mitochondrial group include the development of mouse models of mitochondrial DNA (mtDNA) depletion and amplification disease, and characterization of the role of mitochondria in diabetes, autism, innate immunity, autoimmunity, aging, stem cell biology, and regeneration. We are interested in the detailed mechanisms of tissue-specific mtDNA replication, damage, repair, turnover, and copy number control. This group has also developed novel methods for the study of secreted cellular exosomes and their genomics, proteomics, lipidomics, and metabolomics as non-invasive biomarkers of health and disease. Our marine metagenomics group is developing new methods of environmental DNA isolation and next-generation sequencing to create molecular census tables and trophic architectural maps of contemporary and ancient ecosystems.

Track(s):
MCB


BMS Focus Areas:
Developmental Biology
Neurobiology