Research Interests:
Although therapeutics and diagnostics have demonstrated their potential to detect, prevent and cure diseases, their success hinges upon their ability to cross complex barriers in the body and reach their target intact. Rapid advances in macromolecular engineering have enabled more sophisticated tools to bear on such biomedical challenges. Our research applies cutting edge macromolecular engineering techniques and more broadly Nanotechnology to advance both in vivo molecular imaging and the delivery of drugs and biopharmaceutics.
The most pressing challenges in Biomedical Sciences require a strong foundation in both Chemical and Biological sciences with an Engineering approach to problem solving. The Laboratory for Bioresponsive Materials provides this interdisciplinary environment for training students and postdoctoral associates, while offering a strong foundation in the Chemical and Materials Sciences.
Students and Postdoctoral Associates gain experience in the design, synthesis and engineering of small molecules, polymers and higher order assemblies on the nano and micro scale. To characterize and evaluate the properties and capabilities of the newly developed assemblies, a host of spectroscopic, structural, and biological techniques, including but not limited to, electron microscopy techniques, atomic force microscopy, light scattering, analytical ultracentrifugation, steady-state and time-resolved absorption and emission measurements, X-ray, IR, NMR, chromatography techniques, SEC, MALS, mass spectrometry (and ICP-MS), elemental analysis, cell culture, and confocal and two-photon microscopy are applied.
KEYWORDS: molecular imaging, nanotechnology, drug delivery, gene delivery
Track(s):
Molecular Pharmacology
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