Research Interests:
We are interested in how the brain controls reproduction in mammals, and how this neuroendocrine control is itselfregulated by developmental factors, hormones, neural signals, and environmental signals. Specifically, we study how select neuropeptides in specific brain regions stimulate or inhibit reproductive control centers in the forebrain, and how these processes ultimately affect an animal's reproductive physiology and fertility. We are also interested in the neuroendocrine regulation of reproductive brain circuits during puberty and critical periods of sexual differentiation. akauffman@mail.ucsd.edu
Track(s):
Physiology
MCB
BMS Focus Areas:
Endocrinology
Neurobiology
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1. Kauffman, AS, Gottsch, ML, Roa, J, Byquist, A, Crown, A, Clifton, DK,
Hoffman, GE, Steiner, RA, and M Tena-Sempere. Sexual differentiation of
Kiss1 gene expression in the brain of the rat. Endocrinology, 148:
1774-1783, 2007.
2. Kauffman, AS, Park, JH. McPhie-Lalmansingh, AA, Gottsch, ML, Bodo, C,
Clifton, DK, Steiner, RA, and EF Rissman. The kisspeptin receptor GPR54
is required for sexual differentiation of the brain and behavior. Journal
of Neuroscience, 27(33): 8826-8835; 2007.
3. Kauffman, AS, Clifton, DK, and RA Steiner. Emerging ideas about
kisspeptin-GPR54 signaling the neuroendocrine regulation of reproduction.
Trends in Neuroscience 30: 504-511, 2007.
4. Kauffman, AS. Sexual differentiation and the Kiss1 system: hormonal
and developmental considerations. Peptides 30(1):83-93, 2009.
5. Robertson, JL, Clifton, DK, De la Iglesia, HO, Steiner, RA, and AS
Kauffman. Circadian regulation of Kiss1 neurons: Implications for timing
the preovulatory GnRH/LH surge. Endocrinology. In Press 2009.
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