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We are developing novel genome technologies towards the applications in personalized genome medicine and stem cell research. Our efforts in genome technology development cover three areas: (i) targeted genome resequencing for rapid and efficient identification of coding genetic variants and mutations that are involved in human complex diseases; (ii) allele-specific gene expression and methylation assays for studying regulatory mechanisms related to human diseases; (iii) whole genome sequencing on single cells. Our biological interests lie in the areas of regulatory genomics in human embryonic stem cells, and single cell genomics in microbial communities. In the first area we are performing unbiased and genome-wide search of regulatory DNA polymorphisms that contribute to phenotypic differences of human embryonic stem cells. The long-term goal is to related genetic variants to personalized regenerative medicine. In the second area, we are using cross-disciplinary approaches to dissect the structure and function of microbial communities associated with human.

Track(s):
Genetics