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Retina is a sheet of light-sensing cells that converts complex external visual stimuli to electrical and chemical signals. These signals generated by retina are then transmitted to the brain to form visual images. Collectively, retinal degeneration is the most common cause of irreversible visual loss in the developed world.

The overall goal of my research program is to gain insights into molecular mechanisms of retinal degeneration. We are focusing on most common forms of retinal degeneration: macular degeneration, diabetic retinopathy, glaucoma, and retinitis pigmentosa. To achieve this goal, we employ a variety of approaches including genome wide association studies and linkage analysis to identify key disease genes, and then use transgenic mice, biochemistry and stem cell based transplantation to study the function, mechanism and therapies related to these blinding disorders.

Track(s):
Genetics
MCB

BMS Focus Areas:
Neurobiology
Bioinformatics