Research Interests:
Our laboratory is interested in the molecular pathology of cancer development and innate immune responses. More specifically, we use the blood cell system to study how transcription factors regulate hematopoietic stem cell differentiation and how oncogenes disrupt normal hematopoiesis and promote leukemia development. Furthermore, we study several interferon inducible proteins and their role in regulating innate immune responses related to pathogen infection and cancer development.
Track(s):
Molecular Pathology
BMS Focus Areas:
Cancer Biology
Developmental Biology
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Yan M, Kanbe E, Peterson LF, Boyapati A, Miao Y, Wang Y, Chen IM, Chen Z, Willman CL, Rowley JD, Zhang D-E. A previously unidentified alternatively spliced isoform of t(8;21) transcript promotes leukemogenesis, 2006, Nature Med, 12:945-949.
Okumura F, Zou W, Zhang D-E. ISG15 modification of the eIF4E cognate 4EHP enhances cap structure binding activity of 4EHP, 2007, Genes & Development, 21:255-60.
Malakhova OA, Zhang D-E. ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response, 2008, J. Biol. Chem. 283:8783-7.
Okumura AJ, Peterson LF, Okumura F, Boyapati A, Zhang D-E. t(8;21)(q22;q22) fusion proteins preferentially bind to duplicated AML1/RUNX1 DNA binding sequences to differentially regulate gene expression, 2008, Blood, 112:1392-401.
Ahn E-Y, Yan M, Malakhova OA, Boyapati A, Ommen HB, Hines R, Hokland P, Zhang D-E. Disruption of the zinc-chelating topology of AML1-ETO abrogates SON binding and promotes leukemia, 2008, PNAS, 105:17103-8.
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