Research Interests:
Effects of mechanical forces on gene expression and signal transduction. Biomechanical properties and molecular organization of cell membranes. Energy balance and molecular mechanisms of cell-cell interactions. Transport of macromolecules across vascular endothelium. Blood rheology and microcirculatory dynamics in health and disease. Molecular, cellular, and tissue bioengineering.
Track(s):
Physiology
Molecular Pharmacology
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Flaim, C.J.; Chien, S., and Bhatia, S.: An extracellular matrix
microarray for probing cellular differentiation. Nature Methods
2:119-125, 2005.
Wang, Y.; Botvinick, E.L.; Zhao, Y.; Berns, M.; Usami, S.; Tsien,
R.Y., and Chien, S.: Visualizing the mechanical activation of Src.
Nature, 434:1040-1045, 2005.
Wang, Y.X.; Chang, J.; Chen, K.D.; Li, S.; Julie Li, Y.S.; Wu, C., and
Chien. S.: Selective adapter recruitment and differential signaling
networks by VEGF vs. shear stress. Proc Natl Acad Sci U S A,
104:8875-8879, 2007.
Wang, Y.: Shyy, J.Y-J., and Chien, S.: Fluorescence proteins, live-
cell imaging, and mechanobiology: Seeing is believing. Ann. Rev.
Biomed. Engineering 10:1-38, 2008.
del Alamo, J.C.; Norwich, G.N.; Li, Y.S.; Lasheras, J.C., and Chien
S.: Anisotropic rheology and directional mechanotransduction in
vascular endothelial cells. Proc Natl Acad Sci U S A. 105(40):
15411-15416, 2008.
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