Research Interests:
Cancers arise from mistakes in sending, receiving or interpreting the molecular instructions intended to construct or maintain the tissues of the body. The Oshima laboratory investigates the role of the Ets2 nuclear regulatory molecule in breast and colon cancer using mouse genetic models. Decreasing the amount of Ets2 results in mice in which breast cancers progresses slower. This effect is not due to the action of Ets2 in the tumor, but rather in the normal host tissues surrounding the lesion. In contrast to mammary tumors, decreasing Ets2 results in increasing colon cancers in the mouse. This repressive effect in colon cancer is linked to the role of Ets2 in regulating the self renewal of normal stem cells of the placenta. The formation of trophoblast stem cells from human embryonic stem cells and the possible stem cell origins of breast cancer are additional topics under investigation.
Track(s):
Molecular Pathology
BMS Focus Areas:
Cancer Biology
Stem Cells
|
News