Research Interests:
The Bodmer Laboratory is interested in the molecular mechanisms of organ formation, how patterns are generated and how cells and tissue types assume their correct fates and functions. The Bodmer lab is pursuing this interest by studying the genetic functions and interactions that specify heart development and maintain heart performance in the Drosophila model, in the hope of elucidating basic principles in organogensis and functionality.
Mesoderm, Cardiac Mesoderm, Cardiac Cell Types, Morphogenesis, Heart Function, Aging Heart
Track(s):
Physiology
Genetics
BMS Focus Areas:
Developmental Biology
Endocrinology
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Wessells, R.J., Fitzgerald, E., Cypser, J.R., Tatar, M., Bodmer R. (2004). Insulin regulation of heart function in aging fruit flies. Nature Genetics 36, 1275-1281.
Qian, L., Liu, J., Bodmer, R. (2005). Slit and Robo control cardiac cell polarity and morphogenesis. Curr. Biol. 15, 2271-2278.
Ocorr, K., Reeves, N.L., Wessells, R. J., Fink, M., Chen, H.-S.V., Akasaka, T., Yasuda, S. Metzger, J., Giles, W., Posakony, J.W., Bodmer, R. (2007) KCNQ potassium channel mutations cause cardiac arrhythmias in Drosophila that mimic the effects of aging. PNAS 103, 3943-3948.
Qian, L, Mohapatra, B., Akasaka, T., Liu, J., Ocorr, K., Towbin, J.A., Bodmer, R. (2008). Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease. PNAS, 105, 19833-19838.
Wessells, R.J., Fitzgerald, E., Piazza, N., Ocorr, K., Morley, S., Davies, C., Lim, H.-Y., Mitchell, L., Hayes, M., Oldham, S., Bodmer, R. (2009). d4eBP acts downstream of both dTOR and dFOXO to modulate cardiac functional aging in Drosophila. Aging Cell
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