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Philip E. Bourne
Professor of Pharmacology;
Bioinformatics Focus Leader
Ph.D., Flinders University, Australia
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Research Interests:
Professor Bourne's research is in the area of bioinformatics with emphasis
structural bioinformatics. Interests include structural genomics, protein
structure classification, protein structure prediction, protein-protein
interactions, protein evolution, cell signaling, and apoptosis. His group
is responsible for a number of biological resources, including the Protein
Data Bank, the single worldwide repository for macromolecular structure
data.
Track(s):
Molecular Pharmacology
BMS Focus Areas:
Bioinformatics
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Publications:
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S.L Kinnings, N. Buchmeier, N. Liu, P.J. Tonge L. Xie and P.E. Bourne 2009 Discovery of Novel Drug Leads to Treat Multi-drug and Extensively Drug Resistant Tuberculosis by Repositioning Safe Pharmaceuticals: A Chemical Genomics Approach with Subsequent Biological Validation. PLoS Comp. Biol. 5(7) e1000423. [PDF ]
R.E. Valas, S. Yang and P.E. Bourne 2009 Nothing in Protein Structure Classification Makes Sense Except in the Light of Evolution Current Opinions in Structural Biology 19:1-6 [PDF
L. Xie and P.E. Bourne 2008 Detecting Evolutionary Linkages Across Fold and Functional Space with Sequence Order Independent Profile-profile Alignments. PNAS, 105(14) 5441-5446 [PDF ]
J.L. Fink and P.E.Bourne 2007 Reinventing Scholarly Communication for the Electronic Age. CT Watch, 3(3) 26-31 [HTML ]
H.M. Berman, J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, and P.E. Bourne Nucleic Acid Research 2000 28(1), 235-242. The Protein Data Bank. [PDF file ]
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URL:
http://www.sdsc.edu/pb
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