Research Interests:
Our laboratory is interested in mechanism underlying the regulation of cell growth and apoptosis by G-protein coupled receptors (GPCRs) , specifically the signal transduction pathways by which specific subtypes of GPCRs (those for thrombin, LPA, S1P) are able to effect changes in cell proliferation and survival. We use biochemical, cell and molecular biological techniques to identify pathways and subsequently generate transgenic or knockout mice to assess the physiological role of these pathways in heart failure, brain injury and cancer. Current projects consider the role of the Rho family small G-proteins in regulating phospholipases and gene expression, the effects of Akt activation on mitochondrial function and cell survival , and the role of InsP3 and calcium in controlling the Ca/calmodulin dependent protein kinase (CaMKII) and thereby regulating Ca storage and nuclear HDAC phosphorylation.
Track(s):
Molecular Pharmacology
MCB
BMS Focus Areas:
Cancer Biology
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