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Our laboratory is interested in the cell and molecular biology of the insulin-producing pancreatic islets and in the cellular events that cause islet damage and dysfunction in diabetes mellitus. Our research focuses on a set of proteins and structural features shared by islets and neurons and that include the major autoantigens in type 1 diabetes. Currently, we are investigating the biogenesis, trafficking and function and the role in the pathogenesis of diabetes of a group of islet proteins and vesicle types that, in the central nervous system, play key roles neurotransmission. Additionally, we are exploring the potential of some of these proteins to serve as biomarkers of islet damage.

Track(s):
MCB
Molecular Pharmacology

BMS Focus Areas:
Endocrinology