Research Interests:
Theoretical and experimental investigation of pulmonary gas exchange in animals and man. Development and application of new methods for measuring ventilation-perfusion relationships. Mechanisms/effects of hypoxic vasoconstriction. Effects of O2 breathing, altitude, and exercise on lung function. Determinants of maximum O2 uptake in exercising muscle. Theoretical and experimental exploration of convective and diffusive phenomena that interact to set maximum O2 uptake. Interaction between the biophysics of O2 supply and the biochemistry of O2 utilization. Relationship between muscle structure and O2 transport function. Molecular regulation of muscle angiogenesis. Role of VEGF and HIF-1a in adaptive angiogenic responses to hypoxia, exercise, and disease. Transgenic models of altered angiogenic potential.
Track(s):
Physiology
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Rice, A.J., A.T. Thornton, C.J. Gore, G.C. Scroop, H.W. Greville, H. Wagner, P.D. Wagner and S.R. Hopkins. Pulmonary gas exchange during exercise in highly trained cyclists with arterial hypoxemia. J. Appl. Physiol. 87(5):1802-1812, 1999.
Rossiter, H.B., M. Scadeng, K. Tang, P.D. Wagner, E.C. Breen. Doxycycline treatment prevents alveolar destruction in VEGF-deficient mouse lung. J Cell Biochem. 104(2): 525-535, 2008.
Olfert, I.M., R.A. Howlett, K. Tang, N.D. Dalton, Y. Gu, K.L. Peterson, P.D. Wagner, and E.C. Breen. Muscle-specific VEGF deficiency greatly reduces exercise endurance in mice. J. Physiol. 587.8: 1755-1767, 2009
Howlett, R.A., S.D. Kirkton, N.C. Gonzalez, H.E. Wagner, S.L. Britton, L.G. Koch and P.D. Wagner. Peripheral oxygen transport and utilization in rats following continued selective breeding for endurance running capacity. J. Appl. Physiol. 106(6): 1819-1825, 2009
Rodriguez-Roisin, R., M. Drakulovic, D. Rodriguez, J. Roca, J. Barberá, and P.D. Wagner. Ventilation-perfusion imbalance and chronic obstructive pulmonary disease staging severity. J. Appl. Physiol. 106(6): 1902-1908, 2009
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