Robert H. Tukey
Professor of Pharmacology and Chemistry & Biochemistry
Ph.D., University of Iowa
Our laboratory is investigating the molecular and cellular mechanisms that control expression of the genes involved in xenobiotic and drug metabolism. Much of our work utilizes mouse genetics as a tool to define selective mechanisms that control chromatin configuration and transcriptional control. An emphasis is placed on studying the impact of environmental toxicants on genetically modified animal models that are designed to characterize the key regulatory events linking exposure to metabolism and toxicity.
BMS Focus Areas:
Chen, S., Yueh MF, Evans RM, Tukey, R.H. The Pregnane-X-Receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 Mice. Hepatology. 2: 658-667, 2012. PMC3383890
Fujiwara, R., Chen, S., Karin, M., Tukey, R. H. Reduced expression of UGT1A1 in intestines of humanized UGT1 mice via inactivation of NF-kappa B leads to hyperbilirubinemia. Gastroenterology. 1: 109-118, 2012. PMC3428231
Chen, S., Yueh, MF., Bigo, C., Barbier, O., Wang, K., Karin, M., Nguyen, N., Tukey, RH. Intestinal glucuronidation protects against chemotherapy-induced toxicity by irinotecan (CPT-11). Proc. Natl. Acad. Sci. 110: 19143-19148, 2013. PMID: 24191041.
Yueh, MF., Chen, S., Nguyen, N., Tukey, RH. Developmental onset of bilirubin-induced neurotoxicity involves Toll-like receptor 2-dependent signaling in humanized UDP-glucuronosyltransferase 1 mice. J Boil Chem. 289:4699-4709, 2014. PMID: 24403077.