Professor of Medicine
M.D., University of Southern California School of Medicine, Los Angeles, CA
Communication between cells and their surrounding support structures plays a crucial role as organs develop and grow. My laboratory is interested in studying how the cardiac myocyte interacts with the extracellular matrix as the heart develops in the embryo, and also, as the post-natal heart is stimulated to undergo pathologic growth. Our group utilizes a combination of molecular biological techniques and physiological analyses, along with cell culture, transgenic and knockout mouse models, to study this process. The current principal focus of the lab involves the study of integrins and integrin associated proteins, as signaling and cell-adhesive molecules, during cardiac hypertrophy and heart development.
Key words: Integrins, extracellular matrix, cardiac, transgenic, knockout, murine physiology