Photo of Alexandra C. Newton

Alexandra C. Newton

Professor of Pharmacology
Ph.D., Stanford University
Email: anewton@ucsd.edu

Research Interests:

Our lab investigates the molecular mechanisms of signal propagation and signal termination in the PI3 kinase and diacylglycerol signaling pathways, and how disruption of these mechanisms results in pathophysiologies.  Specifically, we are interested in how deregulation drives cancer, where signal propagation is upregulated, and diabetes, were signal termination is upregulate.   We focus on how protein kinase C and Akt (protein kinase B) are 1] activated by phosphorylation and second messengers, and 2] inactivated by dephosphorylation catalyzed by the new phosphatase and tumour suppressor our lab discovered, PH domain Leucine rich repeat Protein Phosphatase, PHLPP (pronounced 'flip'). Understanding the molecular mechanisms of these processes is of particular relevance to cancer biology where many of these proteins become deregulated.

Track(s)

Molecular Pharmacology

MCB

Selected Publications:

http://newtonlab.ucsd.edu/Publications.htm

Web Page:

http://newtonlab.ucsd.edu