Ronald M. Evans
Adjunct Professor, The Salk Institute and Investigator, Howard Hughes Medical Institute
Ph.D., University of California, Los Angeles
Our laboratory has identified a superfamily of proteins encoding receptors for steroids, retinoids (vitamin A), and thyroid hormones. Analyses of these receptors show they are hormone dependent transcription factors and provide a molecular link between transcriptional regulation and organ physiology. Our isolation of co-factors for these receptors has helped to establish a biochemical basis for hormone signalling. Technology for these studies includes X-ray crystallography, gene knockouts, chromatin modification and transfection. Recently, we have identified two new mammalian hormones controlling adipogenesis and fat metabolism, and are currently characterizing their roles in physiology and human disease. By metabolic engineering of muscle, we have created a fatigue resistant "Marathon" mouse that runs twice the distance of normal littermates.
BMS Focus Areas:
Yang, X.-Y., Downes, M., Yu, R.T., Bookout, A.L., He, W., Straume, M., Mangelsdorf, D.J., and Evans, R.M (2006) Nuclear receptor expression links the circadian clock to metabolism. Cell, 126:801-810.
Wan, Y., Chong, L.W., and Evans, R.M. (2007). PPARg Regulates Osteoclastogenesis in Mice. Nature Medicine, 13(12):1496-503.
Yang, X., Ongusaha, P., Miles, P., Zhang, F., Venus So, F., Havstad, J., Kudlow, J.E., Olefsky. J.M. and Evans, R.M. (2008). Phosphoinositide Signaling Links Protein O-GlcNAc Modification to Insulin Resistance. Nature, 451(7181):964-9.
Narkar, V., Downes, M., Yu, R.T., Embler, E., Wang, Y-X., Banayo, E., Mihaylova, M.M., Nelson, M. C., Zou, Y., Juguilon, H., Kang, H., Shaw, R., and Evans, R.M. (2008) AMPK and PPARdelta agonists are exercise mimetics. Cell, 134(3):405-15.
Lamia, K.A., Sachdeva, U.M., DiTacchio, L., Egan, D.F., Vasquez, D.S., Alvarez, J.G., Juguilon, H., Panda, S., Shaw, R.J., Thompson, C.B., and Evans, R.M. (2009) AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation. Science 326(5951):437-40.