Professor of Medicine
Postdoctoral Fellow, Yale University and Nactional Cancer Institute
Regulation of tissue injury, inflammation and repair (as applicable to human liver cirrhosis and lung fibrosis).
Tissue-specific gene expression during liver differentiation and regeneration ( as applicable to liver transplantation).
Mechanisms resulting in obesity and insulin resistance ( as applicable to human obesity and type 2 diabetes)
Emphasis on signal transduction and transcriptional factors using cellular, animal models, transfgenic & KO mice, and human samples to assess relevance.
Focus Area: Molecular Biology
BMS Focus Areas:
. Buck M, Zhang L, Halasz N, Hunter T and Chojkier M. Nuclear export of phosphorylated C/EBPb mediates the inhibition of albumin expression by TNFa. EMBO J 20:6712-6723, 2001.
. Buck M, Poli V, Hunter T and Chojkier M. C/EBPb phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. Mol Cell 8:807-816, 2001.
. Buck M and Chojkier M. Signal transduction in the liver: C/EBPb modulates cell proliferation and survival. Hepatology 37:731-8, 2003.
. Buck M and Chojkier M. C/EBPβ phosphorylation rescues macrophage dysfunction and apoptosis induced by anthrax lethal toxin. Am J Physiol Cell Physiol 293:1788-1796, 2007.
. Buck M and Chojkier M. A ribosomal S-6 kinase mediated signal to C/EBPβ is critical for the development of liver fibrosis. PLoS ONE 2:e1372, 2007