Adam J. Engler
Assistant Professor of Bioengineering
Ph.D., University of Pennsylvania
Our research is focused on how cell behavior is directed by the extracellular matrix (ECM), a 3-dimensional fibrillar scaffold to which cells adhere, during development, disease, and aging. We use a variety of stem cell culture models (mouse and human; both embryonic and adult) as well as many animal models (fly, chicken, mouse, and rat) in which to study how ECM affects pathologies including myocardial infarction and muscular dystrophy. We have significant efforts to explore the molecular and cellular mechanisms of these non-growth factor-mediated mechanisms.
BMS Focus Areas:
Holle, A.W., Tang, X., Vijayraghavan, D., Vincent, L.G., Fuhrmann, A., Choi, Y.S., del Alamo, J.C., and Engler, A.J. “In Situ Mechanotransduction via Vinculin Regulates Stem Cell Myogenesis” Stem Cells, 2013 (in press; DOI: 10.1002/stem.1490)
Taylor-Weiner, H., Schwarzbauer, J.E., and Engler, A.J. “Defined Extracellular Matrix Components are Necessary for Definitive Endoderm Induction” Stem Cells, 2013 (in press; DOI: 10.1002/stem.1453)
Choi, Y.S., Vincent, L.G., Lee, A.R., Dobke, M.K., and Engler, A.J. “Mechanical Derivation of Functional Myotubes from Adipose-Derived Stem Cells.” Biomaterials, 2012. 33(8): 2482-2491
Kaushik, G., Zambon, A., Fuhrmann, A., Bernstein, S.I., Bodmer, R., Engler, A.J., and Cammarato, A. “Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic function.” J Cell Mol Med, 2012. 16(8): 1656-1662
Engler, A.J., Humbert, P.O. Wehrle-Haller, B., and Weaver, V.M. “Multiscale Modeling of Form and Function” Science, 2009. 208: 208-212.
Oh, S., Brammer, K.S., Li, Y.S.J., Teng, D., Engler, A.J., Chien, S., and Jin, S. “Stem Cell Fate Dictated Solely by Altered Nanotube Dimension” Proc Nat Acad Sci USA, 2009. 106(7): 2130-2135.
Engler, A.J., Sen, S., Sweeney, H.L., and Discher, D.E. “Matrix Elasticity Directs Stem Cell Lineage Specification” Cell, 2006. 126(4): 677-689.