Photo of Adam J.  Engler

Adam J. Engler

Assistant Professor of Bioengineering
Ph.D., University of Pennsylvania
Email: aengler@ucsd.edu

Research Interests:

Our research is focused on how cell behavior is directed by the extracellular matrix (ECM), a 3-dimensional fibrillar scaffold to which cells adhere, during development, disease, and aging. We use a variety of stem cell culture models (mouse and human; both embryonic and adult) as well as many animal models (fly, chicken, mouse, and rat) in which to study how ECM affects pathologies including myocardial infarction and muscular dystrophy. We have significant efforts to explore the molecular and cellular mechanisms of these non-growth factor-mediated mechanisms.

Track(s)

MCB

Physiology

BMS Focus Areas:

Stem Cells

Glycobiology

Selected Publications:

Holle, A.W., Tang, X., Vijayraghavan, D., Vincent, L.G., Fuhrmann, A., Choi, Y.S., del Alamo, J.C., and Engler, A.J.In Situ Mechanotransduction via Vinculin Regulates Stem Cell Myogenesis” Stem Cells, 2013 (in press; DOI: 10.1002/stem.1490)

Taylor-Weiner, H., Schwarzbauer, J.E., and Engler, A.J. “Defined Extracellular Matrix Components are Necessary for Definitive Endoderm Induction” Stem Cells, 2013 (in press; DOI: 10.1002/stem.1453)

Choi, Y.S., Vincent, L.G., Lee, A.R., Dobke, M.K., and Engler, A.J. “Mechanical Derivation of Functional Myotubes from Adipose-Derived Stem Cells.” Biomaterials, 2012. 33(8): 2482-2491

Kaushik, G., Zambon, A., Fuhrmann, A., Bernstein, S.I., Bodmer, R., Engler, A.J., and Cammarato, A. “Measuring passive myocardial stiffness in Drosophila melanogaster to investigate diastolic function.” J Cell Mol Med, 2012. 16(8): 1656-1662

Engler, A.J., Humbert, P.O. Wehrle-Haller, B., and Weaver, V.M. “Multiscale Modeling of Form and Function” Science, 2009. 208: 208-212.

Oh, S., Brammer, K.S., Li, Y.S.J., Teng, D., Engler, A.J., Chien, S., and Jin, S.  “Stem Cell Fate Dictated Solely by Altered Nanotube Dimension” Proc Nat Acad Sci USA, 2009. 106(7): 2130-2135.

Engler, A.J., Sen, S., Sweeney, H.L., and Discher, D.E. “Matrix Elasticity Directs Stem Cell Lineage Specification” Cell, 2006. 126(4): 677-689.

Web Page:

http://ecm.ucsd.edu