Photo of Kun-Liang Guan

Kun-Liang Guan

Professor of Pharmacology
Ph.D., Purdue University
Email: kuguan@ucsd.edu

Research Interests:

The research in our laboratory mainly focuses on signal transduction in regulating cell growth and organ size.  We study the TSC-mTOR and hippo-YAP pathways.  Dysregulation of these pathways has been frequently observed in human diseases, particularly cancer.  The TSC-mTOR pathway plays a major role in cell size control by promoting biosynthesis and inhibiting autophagy. The Hippo tumor suppressor pathway regulates organ size and tissue homeostasis.  Current research includes: 1) mechanisms of mTOR in nutrient signaling and autophagy regulation; 2) regulation of the Hippo pathway by cell-cell contact and G-protein coupled receptor signaling.

Track(s)

Molecular Pharmacology

MCB

BMS Focus Areas:

Cancer Biology

Stem Cells

Selected Publications:

  1. Kim, J., Kundu, M., Viollet, B., and Guan K-L., (2011) AMPK and mTOR regulate autophagy via direct phosphorylation of ULK1. Nature Cell Biol. 13, 132-141.

    Yu, F-X., Zhao, B., Panupinthu, etal., and Guan, K-L. (2012) Regulation of the Hippo-YAP pathway by G-protein coupled receptor signaling. Cell 150, 780-91.

    Tumaneng, K., Schlegelmilch, K., Russell, R.C., et al., and Guan, K-L. (2012) YAP mediates crosstalk between the Hippo and PI3K-TOR pathways by suppressing PTEN via miR-29. Nature Cell Biol. 14, 1322-1329.

    Kim, J., Kim, Y.C., Fang, C., et al., Guan, K-L. (2013) Diff erential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303.

    Russell, R.C., Tian, Y., Yuan, H., et al., Guan, K-L. (2013) ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase. Nature Cell Biol. 15, 741-50.

    Yu, FX., Luo, J., Mo, J-S., et al,, Zhang, K. and Guan, K-L. (2014) Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell 25, 822-830.

Web Page:

http://moores.ucsd.edu/guanlab/