Professor of Pharmacology
Ph.D., Purdue University
The research in our laboratory mainly focuses on signal transduction in regulating cell growth and organ size. We study the TSC-mTOR and hippo-YAP pathways. Dysregulation of these pathways has been frequently observed in human diseases, particularly cancer. The TSC-mTOR pathway plays a major role in cell size control by promoting biosynthesis and inhibiting autophagy. The Hippo tumor suppressor pathway regulates organ size and tissue homeostasis. Current research includes: 1) mechanisms of mTOR in nutrient signaling and stress response; 2) regulation of the Hippo pathway by cell-cell contact and G-protein coupled receptor signaling.
BMS Focus Areas:
Yu, F-X., Zhao, B., Panupinthu, etal., and Guan, K-L. (2012) Regulation of the Hippo-YAP pathway by G-protein coupled receptor signaling. Cell 150, 780-91.
Kim, J., Kim, Y.C., Fang, C., et al., Guan, K-L. (2013) Diff erential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy. Cell 152, 290-303.
Russell, R.C., Tian, Y., Yuan, H., et al., Guan, K-L. (2013) ULK1 induces autophagy by phosphorylating Beclin-1 and activating Vps34 lipid kinase. Nature Cell Biol. 15, 741-50.
Yu, FX., Luo, J., Mo, J-S., et al,, Zhang, K. and Guan, K-L. (2014) Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell 25, 822-830.
Jewell, J.L., Kim, Y.C., Russell, R.C., Yu, F.X., Park, H.W., Plouffe, S.W., Tagliabracci, V.S., and Guan, K-L. (2015) Differential Regulation of mTORC1 by Leucine and Glutamine. Science 347, 194-198.
Park, H. W., Kim, Y.C., Yu, B., Moroishi, T., Mo, J-S., Plouffe, S.W., Meng, Z., Lin, K.C., Yu, F.X., Alexander, C.M., Wang, C., and Guan, K-L. (2015) Alternative Wnt Signaling Activates YAP/TAZ . Cell 162, 780-794.