Photo of Gerry R. Boss

Gerry R. Boss

Professor of Medicine
M.D., University of California, Irvine

Research Interests:

Regulation of purine nucleotide synthesis during the cell cycle and by the PI3k/Akt pathway.  Development of a new nitric oxide-releasing drug, and a drug that neutralzes cyanide, reactive oxygen species, and reactive nitrogen species.  Development of a field-deployable hand-held sensor for measuring cyanide in blood and saliva.



Molecular Pharmacology

BMS Focus Areas:

Cancer Biology

Structural Chemical Biology

Selected Publications:

1. Wang W, Fridman A, Blackledge W, Connelly S, Wilson IA, Pilz RB, Boss GR. The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. J Biol Chem., 2009, 284:3521-3528 

2. Casteel DE, Zhuang S, Zeng Y, Perrino FW, Boss GR, Goulian M, Pilz RB. A DNA polymerase-α-{middle dot}primase cofactor with homology to replication protein A-32 regulates DNA replication in mammalian cells. J Biol Chem., 2009, 284:5807-5818

3. Rangaswami H, Marathe N, Zhuang S, Chen Y, Yeh JC, Frangos JA, Boss GR, Pilz RB. Type II cGMP-dependent protein kinase mediates osteoblast mechanotransduction. J Biol Chem., 2009, 284:14796-14808.

4. Ma, J, Dasgupta, PK, Blackledge, W, and Boss, GR.  Cobinamide-based cyanide analysis by multiwavelength spectrometry in a liquid core waveguide.  Anal. Chem. 82:6244-6250, 2010

5. Blackledge, WC, Blackledge, CW, Griesel, A, Mahon, SB, Brenner, M, Pilz, RB, and Boss, GR.  New facile method to measure cyanide in blood.  Anal. Chem. 82:4216-4221, 2010.

6.  Brenner, M, Mahon, SB, Lee, J, Kim, J, W, Mukai, Goodman, S, Kreuter, KA, Ahdout, R, Mohammad, O, Sharma, VS, Blackledge, W, and Boss, GR.  Comparison of cobinamide to hydroxocobalamin in reversing cyanide physiologic effects in rabbits using diffuse optical spectroscopy.  J. Bio. Optics 15:017001-017008, 2010.

7. Chan, A, Balasubramanian, M, Blackledge, W, Mohammad, OM, Alvarez, L, Boss, GR, Bigby, TD.  Cobinamide is superior to other treatments in a mouse model of cyanide poisoning.  Clin.Toxicol., 48:709-717, 2010.  PMID: 20704457

8. Rangaswami H, Schwappacher R, Marathe N, Zhuang S, Casteel DE, Haas B, Chen Y, Pfeifer A, Kato H, Shattil S, Boss GR, Pilz RB.  Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblastsSci Signal. 2010 Dec 21;3(153):ra91.  PMID21177494

9. Ma, J, Ohira, S-I, Mishra, SK, Puanngam, M, Dasgupta, PK, Mahon, SB, Brenner, M, Blackledge, W, and Boss, GR.  Rapid point of care analyzer for the measurement of cyanide in blood.  Anal. Chem., 83:4319-4324, 2011.  PMID:2155392

10. Chan, A, Crankshaw, DL, Monteil, A, Patterson, SE, Nagasawa, HT, Briggs, JE, Kozocas, JA, Mahon, SB, Brenner, M, Pilz, RB, Bigby, TD, Boss, GR.  The combination of cobinamide and sulfanegen is highly effective in mouse models of cyanide poisoning.  Clin. Toxicol  49:366-373, 2011. 21740135