November 22, 2009



 

 Molecular Pharmacology

Faculty Contact:
Joan Heller Brown (jhbrown@ucsd.edu)

The Molecular Pharmacology Track is organized through the Department of Pharmacology, a basic science department in the School of Medicine and School of Pharmacy and Pharmaceutical Sciences (SPPS) and includes faculty in several other School of Medicine and Campus departments.   An NIGMS training grant in Pharmacological Sciences provides financial support, travel and other educational benefits to selected students in this track.

Pharmacology is broadly defined as a discipline that investigates the effects of chemical interventions on biological systems.  The Molecular Pharmacology program at UCSD is renowned for its strength in elucidating basic cellular and molecular mechanisms of signal transduction that lead to drug target identification and ultimately to drug discovery.  Many of the faculty affiliated with this track have research efforts that impact directly on human health, supported by NIH grants on nuclear oncogenes, inflammatory diseases, the genetics of hypertension, cardiovascular regulation, pain regulation, and neurological disease.

Research directions also include computational and molecular science, catalyzed by an affiliation with the San Diego Supercomputer center, and focusing on structure-guided drug design and bioinformatics.  Cross campus efforts in environmental health sciences and pharmacogenomics, which include many Pharmacology Track faculty, have been launched through major NIH funded project grants.  Adjunct faculty at the Salk Institute, the Scripps Research Institute, the Burnham Institute and in the local biotechnology and pharmaceutical industry are also involved with graduate education in this track creating a natural bond for cross fertilization and communication that bridges the programs basic science efforts, and enhances endeavors in drug discovery. 

Participating BMS Faculty:

Joseph A. Adams

Adah Almutairi

Kim E. Barrett

Philip E. Bourne

Joan Heller Brown

Laurence L. Brunton

Dennis A. Carson

Steven D. Chessler

Shu Chien

Jerold Chun

James W. Covell

Edward A. Dennis

Jack E. Dixon

Pieter Dorrestein

Mark H. Ellisman

Ronald M. Evans

Sylvia Evans

Marilyn G. Farquhar

James R. Feramisco

Seth Field

Pradipta Ghosh

Mark H. Ginsberg

Kun-Liang Guan

Asa Gustafsson

Tracy M. Handel

Vivian Hook

Stephen B. Howell

Paul A. Insel

William J. Joiner

Michael Karin

Kenneth Kaushansky

Elizabeth Komives

Ronald Kuczenski

Hyam Leffert

Martin Marsala

J. Andrew McCammon

Alexandra C. Newton

Sanjay Nigam

Victor Nizet

Daniel O'Connor

Ana Pajor

Hemal Patel

Morton P. Printz

Tariq Rana

Bing Ren

Sanford Shattil

Charles Stevens

Palmer W. Taylor

Susan Taylor

Lynn Ten Eyck

JoAnn Trejo

Roger Y. Tsien

Robert H. Tukey

Wylie W. Vale

Francisco Javier Villarreal

Nicholas J.G. Webster

Virgil L. Woods, Jr.

Tony L. Yaksh

Jing Yang

Jason X. Yuan

Huilin Zhou




Adjunct Faculty in Department of Pharmacology – Other faculty who are affiliated with and involved in educational efforts of the Department of Pharmacology or SPPS are listed on the Pharmacology Department website.

Required coursework for BMS students

BMS students take a core curriculum that provides the foundation to allow them to specialize in any of the offered tracks, focus areas, or customized study. In the Fall quarter, "Molecules to Organisms" provides a systematic approach to current Biomedical Research, using analysis of selected topics to focus on the process of research discovery and its critical evaluation. "Seminar in Biomedical Research" includes attendance at one of the UCSD seminar series and is designed to provoke critical discussion of the presented findings and scientific approaches in a small group setting. BMS students also take short courses in statistical analysis of data and ethics in research in the third quarter of their first year.


Specialized Coursework (individualization or substitution is possible)
Units
  BIOM 255 Winter Qtr;Drugs and Disease I: (Insel, Barrett)
3
  BIOM 255 Spring Qtr:Drugs and Disease II: (Brown, Calcutt)
3
  BIOM 231 Molecular Toxicology and Toxicogenomics (Tukey)
3
  BIOM/PHARM 201 Structural Bioinformatics (Bourne)
*
BIOM 205 Modeling of Biological Marcomolecules (Ten Eyck)
2
  BIOM 207 Internet Resources and Data Analysis (Bourne) 
2
  PHARM 250 Systems Pharmacology & Translational Biology (Three week summer course; Brunton)
3
  BIOM 230 Molecular and Structural Pharmacology (Printz)
3
  BIOM 275 Seminars in Pharmacology (Yaksh, Karin)
2
  BIOM 234 Drug Discovery or Careers in Biomedical Science (Heller Brown)
1
  PHARM/BIOM 235 Pharmacogenomics (O’Connor)
2
  BIOM Fluorescence Tools for Cellular and Molecular Events (Tsien)
2
  BIOM 231 Contemporary Topics in Pharmacology (various)
2

Non-Course Requirements:

Pharmacology Research Discussion (1 unit):  students and postdoctoral fellows present their research weekly.

Signal Transduction Journal Club (1 unit):  students read and critically analyze recent papers in the field.